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dc.contributor.authorRivera, Yordanka Pina
dc.contributor.authorRwegerera, Godfrey Mutashambara
dc.contributor.authorChowdhury, Wahhab
dc.contributor.authorChobanga, Kudra Jumanne
dc.contributor.authorMilan, Alexei Ortiz
dc.date.accessioned2017-11-23T12:51:33Z
dc.date.available2017-11-23T12:51:33Z
dc.date.issued2017-10-10
dc.identifier.citationRivera, Y.P. et al. (2017) Leydig cell tumor of the testis presenting with gynaecomastia due to hyperprolactinemia after orchiectomy. Case Reports in Internal Medicine. Vol. 4, No. 4, pp. 28-32en_US
dc.identifier.issn2332-7243 (print)
dc.identifier.issn2332-7251 (online)
dc.identifier.urihttp://hdl.handle.net/10311/1762
dc.description.abstractLeydig cell tumors (LCT) are rare and represent 1% to 3% of all tumors of the testis. LCTs can either be benign or malignant with clinical presentation varying from testicular mass associated with endocrinal manifestations to metastatic lesions in case of malignant tumors. We describe a 25-year-old man who presented with an isolated painless mass of the left testes which was confirmed by ultrasonography. An orchiectomy was subsequently performed and the histopathological analysis revealed a leydig cell tumor. Three months after surgery, the patient presented with bilateral gynaecomastia; estradiol, testosterone and gonadotropin levels as well as tumor markers (carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and human chorionic gonadotropin ( -HCG) were within normal ranges but prolactin was high in two different measurements. No evidence of tumor recurrence or metastases was found and different underlying causes of hyperprolactinemia including use of drugs, pituitary adenoma, hypothyroidism and renal failure were ruled out. After 6 month of treatment with Cabergoline the prolactin level and breast size were remarkably reduced. Patients with benign LCT have a favourable prognosis but in order to rule out tumor recurrence or a persistent effect of their hormonal disorder, follow-up should include regular hormonal and imaging studies.en_US
dc.language.isoenen_US
dc.publisherSciedu Press, http://web.sciedu.ca/en_US
dc.rightsAvailable under creative commonsen_US
dc.subjectTesticular neoplasmen_US
dc.subjectOrchiectomyen_US
dc.subjectMale breast enlargementen_US
dc.subjectHyperprolactinemiaen_US
dc.titleLeydig cell tumor of the testis presenting with gynaecomastia due to hyperprolactinemia after orchiectomyen_US
dc.typePublished Articleen_US
dc.linkhttps://doi.org/10.5430/crim.v4n4p28en_US


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